5-甲基色胺衍生物的合成
PDF下载 (396)朱海峰,陆海晶,余肖平,梁洪泽*,金海晓,周 雄.5-甲基色胺衍生物的合成[J].宁波大学学报(理工版),2013,27(01):80-83.DOI:
ZHU Hai-feng,LU Hai-jing,YU Xiao-ping,LIANG Hong-ze*,JIN Hai-xiao,ZHOU Xiong.Synthesis of 5-Methyltryptamine Derivatives[J].Journal of Ningbo University(Natural Science & Engineering Edition),2013,27(01):80-83.DOI:
| Title: | Synthesis of 5-Methyltryptamine Derivatives |
| 作者: | 朱海峰, 陆海晶, 余肖平, 梁洪泽*, 金海晓, 周 雄 |
| Author(s): | ZHU Hai-feng, LU Hai-jing, YU Xiao-ping, LIANG Hong-ze*, JIN Hai-xiao, ZHOU Xiong |
| 关键词: | 5-甲基色胺盐酸盐; 酰胺; N-羟基琥珀酰亚胺 |
| Keywords: | 5-methyltryptamine hydrochloride; amide; N-hydroxysuccinimide |
| 分类号: | O622.6 |
| 文献标识码: | A |
| 摘要: | 以5-甲基色胺盐酸盐和邻溴苯乙酸为例, 研究了5-甲基色胺衍生物的合成方法. 在室温下用二环己基碳二亚胺(DCC)作为脱水剂, N-羟基琥珀酰亚胺(NHS)活化酯法一锅法合成5-甲基色胺衍生物, 并通过FTIR、MS、1H NMR、13C NMR确定了目标化合物结构. |
| Abstract: | The synthetic method of 5-methyltryptamine derivatives has been studied using 5-methyltryptamine hydrochloride and 2-bromophenylacetic acid as the test compounds. The results show that by combining dicyclohexylcarbodiimide(DCC) as a condensation reagent, and N-hydroxysuccinimide(NHS) as an activating reagent, a series of amides based on 5-methyltryptamine and substituted phenylacetic acids are synthesized with high yields at room temperature in one pot procedure. The structures of all the products are confirmed by FTIR, MS, 1H NMR and 13C NMR spectra |
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| 备注/Memo: | 收稿日期: 2013?01?20. 宁波大学学报（理工版）网址: http://journallg.nbu.edu.cn/基金项目: 国家自然科学基金（20903058）; 宁波市自然科学基金（2010A610027）; 宁波大学王宽诚基金.第一作者: 朱海峰（1985－）, 男, 黑龙江齐齐哈尔人, 在读硕士研究生, 主要研究方向: 合成化学. E-mail: zhuhaifeng@nbu.edu.cn*通信作者: 梁洪泽（1964－）, 男, 安徽马鞍山人, 博士/教授, 主要研究方向: 合成化学. E-mail: lianghongze@nbu.edu.cn 宁波大学学报（理工版）网址：http://journallg.nbu.edu.cn/ |
