利用Monte-Carlo模拟评价基因水平的关联分析方法
PDF下载 (398)桂娟娟,罗旭红,张添方,华启航,董长征 *.利用Monte-Carlo模拟评价基因水平的关联分析方法[J].宁波大学学报(理工版),2015,28(04):104-108.DOI:
GUI Juan-juan,LUO Xu-hong,ZHANG Tian-fang,HUA Qi-hang,DONG Chang-zheng *.Evaluation of Gene Based Association Tests by Monte-Carlo Simulation[J].Journal of Ningbo University(Natural Science & Engineering Edition),2015,28(04):104-108.DOI:
| Title: | Evaluation of Gene Based Association Tests by Monte-Carlo Simulation |
| 作者: | 桂娟娟, 罗旭红, 张添方, 华启航, 董长征 * |
| Author(s): | GUI Juan-juan, LUO Xu-hong, ZHANG Tian-fang, HUA Qi-hang, DONG Chang-zheng * |
| 关键词: | 遗传关联数据; 基因水平的关联分析; Monte-Carlo模拟; 统计效能 |
| Keywords: | genetic association data; gene based association test; Monte-Carlo simulation; power |
| 分类号: | Q51 |
| 文献标识码: | A |
| 摘要: | 采用Monte-Carlo模拟了多种参数条件下的遗传关联数据, 计算多种基因水平的关联分析方法的统计效能. 结果显示: 主成分Logistic回归分析(累积贡献率为95%)和我们之前发展的基于LD结构和Fisher组合法的新方法(LD-Fisher)在多种参数条件下都具有很高的统计效能, Fisher组合法只有在单个易感SNP的P值较小时或者存在多个P值不太小的易感SNP时表现较好. 主成分Logistic回归分析和LD-Fisher可以作为基因水平关联分析的较为理想的分析方法. |
| Abstract: | Monte-Carlo is adopted to evaluate the power of multiple gene based association tests. With PCA logistic regression (95% cumulative variance) and our previously developed method, the LD-Fisher is found to have the highest power, and performs well under all simulated circumstances. Fisher combination test presents high power only if the P value of the susceptibility SNP takes very small value or there are multiple susceptibility SNPs. In conclusion, PCA logistic regression and LD-Fisher can be used as gene based association tests for complex diseases. |
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| 备注/Memo: | 收稿日期: 2014-04-24. 宁波大学学报（理工版）网址: http://journallg.nbu.edu.cn/ 基金项目: 国家自然科学基金（31000594）; 浙江省自然科学基金（Y2100240）; 宁波市自然科学基金（2015A610190）; 宁波大学学科项目（XKL141060）. 第一作者: 桂娟娟（1989－）, 女, 浙江安徽人, 在读硕士研究生, 主要研究方向: 生物信息学和统计遗传学. E-mail: 852042146@qq.com *通信作者: 董长征（1978－）, 男, 浙江丽水人, 博士/副教授, 主要研究方向: 生物信息学和统计遗传学. E-mail: dongchangzheng@nbu.edu.cn 宁波大学学报（理工版）网址：http://journallg.nbu.edu.cn/ |
