PCL基聚合物的制备及其在生物医学工程中的应用
PDF下载 (18850)韦茜茜 1,金嘉长 1,周 密 1,王 剑 2,王幸媛 1,竺亚斌 1*.PCL基聚合物的制备及其在生物医学工程中的应用[J].宁波大学学报(理工版),2018,31(4):36-45.DOI:
WEI Qian-qian 1,JIN Jia-chang 1,ZHOU Mi 1,WANG Jian 2,WANG Xing-yuan 1,ZHU Ya-bin 1*.The preparation and application of PCL-based polymers in biomedical engineering[J].Journal of Ningbo University(Natural Science & Engineering Edition),2018,31(4):36-45.DOI:
| Title: | The preparation and application of PCL-based polymers in biomedical engineering |
| 作者: | 韦茜茜 1, 金嘉长 1, 周 密 1, 王 剑 2, 王幸媛 1, 竺亚斌 1* |
| Author(s): | WEI Qian-qian 1, JIN Jia-chang 1, ZHOU Mi 1, WANG Jian 2, WANG Xing-yuan 1, ZHU Ya-bin 1* |
| 关键词: | 聚己内酯; 生物降解性; 生物相容性; 组织工程支架; 药物控释 |
| Keywords: | polycaprolactone; biodegradability; biocompatibility; scaffold; controlled drug release |
| 分类号: | R31 |
| 文献标识码: | A |
| 摘要: | 聚己内酯(PCL)具有良好力学性能、生物相容性和生物降解性. 其在催化剂、加热等适当条件下, 可与其他如聚乙二醇(PEG)、聚乳酸(PLA)、聚乙交酯(PGA)等单体或低聚物发生共聚, 以改善聚合物性能; 也可通过与其他聚合物共混; 或者在PCL材料表面化学接枝其他化合物, 以得到性能更为理想的聚合物材料. 这些PCL基材料已在生物医学工程领域中得到广泛关注和开发应用, 尤其作为组织损伤修复的支撑材料、药物负载和可控释放的承载系统等方面, 具有很大的发展空间与应用潜能. 本文将就这方面的基础研究和应用作一综述. |
| Abstract: | Polycaprolactone (PCL) possesses good mechanical property, including biocompatibility and biodegradability. PCL can react with some monomers or oligomers, such as poly(ethylene glycol) (PEG), polylactide (PLA), polyglycolide (PGA) and polyurethane (PU) etc. under proper conditions like catalysts or heats, aiming at improving the performance of PCL-based polymers. In addition, PCL can blend with other polymers or graft given biomacromolecules via surface modification to promote the materials’ characteristics. These materials have been extensively studied for applications in tissue engineering, regenerative medicine and drug delivery system with controlled release. This paper will review the preparations of PCL-based polymers and their applications in biomedical engineering. |
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| 备注/Memo: | 收稿日期: 2017－05－09. 宁波大学学报（理工版）网址: http://journallg.nbu.edu.cn/基金项目: 国家自然科学基金（81471797）; 宁波市创新团队项目（2015B11050）.第一作者: 韦茜茜（1990－）, 女, 广西南宁人, 在读硕士研究生, 主要研究方向: 组织工程. E-mail: weixixi0727@163.com*通信作者: 竺亚斌（1967－）, 女, 浙江宁波人, 教授, 主要研究方向: 组织工程. E-mail: zhuyabin@nbu.edu.cn 宁波大学学报（理工版）网址：http://journallg.nbu.edu.cn/ |
