绝经后女性血清性激素结合蛋白水平与骨质疏松症的相关性研究
PDF下载 (486)刘 芳 牛亚丹,李冬梅,王 俊,李宇宁,葛梦丹,徐冉行,徐雷艇.绝经后女性血清性激素结合蛋白水平与骨质疏松症的相关性研究[J].宁波大学学报(理工版),2019,32(3):99-103.DOI:
LIU Fang,NIU Ya-dan,LI Dong-mei,WANG Jun,LI Yu-ning,,GE Meng-dan,XU Ran-xing,XU Lei-ting.Association between serum sex hormone binding globulin and osteoporosis in postmenopausal women[J].Journal of Ningbo University(Natural Science & Engineering Edition),2019,32(3):99-103.DOI:
| Title: | Association between serum sex hormone binding globulin and osteoporosis in postmenopausal women |
| 作者: | 刘 芳 牛亚丹, 李冬梅, 王 俊, 李宇宁, 葛梦丹, 徐冉行, 徐雷艇, XU Ran-xing, XU Lei-ting |
| Author(s): | LIU Fang, NIU Ya-dan, LI Dong-mei, WANG Jun, LI Yu-ning, , GE Meng-dan, XU Ran-xing, XU Lei-ting |
| 关键词: | 骨质疏松症; 骨密度; 性激素结合蛋白; 睾酮 |
| Keywords: | osteoporosis; bone mineral density; sex hormone binding globulin; testosterone |
| 分类号: | R592 |
| 文献标识码: | A |
| 摘要: | 为探讨性激素结合蛋白(sex hormone binding globulin, SHBG)与骨质疏松症(osteoporosis, OP)患病风险之间的关系, 用电化学发光法检测了237名绝经后女性血清SHBG和睾酮水平, 并采用双能X线骨密度(bone mineral density, BMD)测定仪测量了腰椎L2-4和股骨颈(femoral neck, FN)的BMD. 结果发现SHBG与L2-4和FN的BMD均呈负相关(r=-0.356和-0.303, P<0.01), 校正体重指数(body mass index, BMI)和年龄后仍呈负相关(P<0.05). SHBG水平独立解释了2.0%的L2-4 BMD的变异和1.3%的FN BMD的变异. 高SHBG组受试者OP患病率显著高于中SHBG组(OR=3.22, P=0.001)和低SHBG组(OR=4.22, P<0.001), 校正BMI和游离睾酮后差异仍显著(OR=2.32, P=0.040和OR=3.23, P=0.018). 因此, 高SHBG水平是中国绝经后女性人群OP的独立风险因素, 监测外周血SHBG水平可能有助于预测绝经后女性骨质丢失与OP的严重程度. |
| Abstract: | To explore the relationship between sex hormone binding globulin (SHBG) and risk of osteoporosis (OP), serum levels of SHBG and testosterone were measured using electrochemiluminescence and bone mineral density (BMD) at lumbar spine L2-4 and femoral neck by dual energy X-ray absorptiometry in 237 post- menopausal Chinese women. The current study showed that SHBG levels are negatively associated with BMD at L2-4 and femoral neck (r=-0.356 and -0.303, P all<0.01). The associations remained significant after body mass index (BMI) and age (P all<005) was adjusted. Women with high level of serum SHBG have significantly higher risk for OP than those with medium (OR=3.22, P=0.001) and low level (OR=4.22, P<0.001), even adjusted for BMI and free testosterone (OR=2.32, P=0.040 and OR=3.23, P=0.018, respectively). In conclusion, high SHBG level is an independent risk factor for OP in Chinese postmenopausal women. Monitoring serum SHBG may be a useful method for predicting severity of bone loss and osteoporosis in postmenopausal women. |
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| 备注/Memo: | 收稿日期: 2019?02?24. 宁波大学学报（理工版）网址: http://journallg.nbu.edu.cn/ 基金项目: 浙江省自然科学基金（LY16H070001）. 第一作者: 刘芳（1992－）, 女, 甘肃兰州人, 在读硕士研究生, 主要研究方向: 骨质疏松症队列研究. E-mail: lfworke@163.com *通信作者: 徐雷艇（1973－）http://journallg.nbu.edu.cn/ |
