富血小板血浆与肌腱干细胞治疗跟腱病的研究进展
PDF下载 (217)章 松,毛海蛟.富血小板血浆与肌腱干细胞治疗跟腱病的研究进展[J].宁波大学学报(理工版),2023,36(6):114-120.DOI:10.20098/j.cnki.1001-5132.2023.0243
ZHANG Song,MAO Haijiao.Research progress of platelet-rich plasma and tendon stem cells in the treatment of achilles tendinopathy[J].Journal of Ningbo University(Natural Science & Engineering Edition),2023,36(6):114-120.DOI:10.20098/j.cnki.1001-5132.2023.0243
| Title: | Research progress of platelet-rich plasma and tendon stem cells in the treatment of achilles tendinopathy |
| 作者: | 章 松, 毛海蛟 |
| Author(s): | ZHANG Song, MAO Haijiao |
| 关键词: | 跟腱病; 富血小板血浆; 肌腱干细胞; 组织工程 |
| Keywords: | achilles tendinopathy; platelet-rich plasma; tendon stem cell; tissue engineering |
| 分类号: | R686.1 |
| DOI: | 10.20098/j.cnki.1001-5132.2023.0243 |
| 文献标识码: | A |
| 摘要: | 跟腱病是对复杂、多方面病理跟腱的总称, 在临床中突出的特征表现是跟腱及腱周组织的肿胀、疼痛和跟腱功能受限. 跟腱作为人体最大、最强壮的肌腱, 是踝关节跖屈的主要力量, 跟腱病的发生会严重影响患者的生活质量. 目前对于跟腱病治疗多以保守治疗为主, 而伴随着组织工程和再生医学的发展, 其中富血小板血浆(Platelet-Rich Plasma, PRP)与肌腱干细胞(Tendon Stem Cells, TSCs)治疗肌腱相关疾病成为近期研究的热点. 本文回顾了与PRP和TSCs治疗跟腱病相关的研究, 对PRP和TSCs治疗跟腱病的进展作一综述. |
| Abstract: | Achilles tendinopathy is a general term for a complex, multifaceted pathology of the achilles tendon. The prominent features in clinical practice are swelling, pain, and limited function of the achilles tendon and peritendinous tissue. As the largest and strongest tendon in the body, the achilles tendon is the main force for plantarflexion of the ankle joint. The occurrence of achilles tendinopathy can seriously affect the quality of life of patients. Currently, the treatment of achilles tendinopathy is mainly conservative. Due to the development of tissue engineering and regenerative medicine, Platelet-Rich Plasma (PRP) and Tendon Stem Cells (TSCs) for tendon-related diseases have become a hot topic of recent research. In this article, we review the research progress related to PRP and TSCs for achilles tendinopathy. |
| 参考文献 /References: | [1] Millar N L, Silbernagel K G, Thorborg K, et al. Tendino- pathy[J]. Nature Reviews Disease Primers, 2021, 7(1):1-21. [2] Mahan J, Damodar D, Trapana E, et al. Achilles tendon complex: The anatomy of its insertional footprint on the calcaneus and clinical implications[J]. Journal of Ortho- paedics, 2019, 17:221-227. [3] Periasamy M, Venkatramani H, Shanmuganathan R S. Management of chronic achilles tendon injuries: Review of current protocols and surgical options[J]. Indian Journal of Plastic Surgery, 2019, 52(1):109-116. [4] Silbernagel K G, Hanlon S, Sprague A. Current clinical concepts: Conservative management of achilles tendino- pathy[J]. Journal of Athletic Training, 2020, 55(5):438- 447. [5] Madhi M I, Yausep O E, Khamdan K, et al. The use of PRP in treatment of achilles tendinopathy: A systematic review of literature[J]. Annals of Medicine and Surgery, 2020, 55:320-326. [6] Van Der Vlist A C, Winters M, Weir A, et al. Which treatment is most effective for patients with achilles tendinopathy? A living systematic review with network meta-analysis of 29 randomised controlled trials[J]. British Journal of Sports Medicine, 2021, 55(5):249-256. [7] Ruiz-Alonso S, Lafuente-Merchan M, Ciriza J, et al. Tendon tissue engineering: Cells, growth factors, scaffolds and production techniques[J]. Journal of Controlled Release, 2021, 333:448-486. [8] De Vos R J, Van Der Vlist A C, Zwerver J, et al. Dutch multidisciplinary guideline on achilles tendinopathy[J]. British Journal of Sports Medicine, 2021, 55(20):1125- 1134. [9] Mao H J, Wang L E, Dong W W, et al. Anatomical feasibility study of flexor hallucis longus transfer in treatment of achilles tendon and posteromedial portal of ankle arthroscopy[J]. Surgical and Radiologic Anatomy, 2018, 40(9):1031-1038. [10] Russo V, El Khatib M, Prencipe G, et al. Scaffold- mediated immunoengineering as innovative strategy for tendon regeneration[J]. Cells, 2022, 11(2):266. [11] Indino C, D’ambrosi R, Usuelli F G. Biologics in the treatment of achilles tendon pathologies[J]. Foot and Ankle Clinics, 2019, 24(3):471-493. [12] James H C W, 周义钦. 肌腱干细胞研究新进展[J]. 国际骨科学杂志, 2015, 36(3):163-167. [13] Padilla S, Sánchez M, Vaquerizo V, et al. Platelet-rich plasma applications for achilles tendon repair: A bridge between biology and surgery[J]. International Journal of Molecular Sciences, 2021, 22(2):824-840. [14] Filardo G, Kon E, Di Matteo B, et al. Platelet-rich plasma injections for the treatment of refractory achilles tendinopathy: Results at 4 years[J]. Blood Transfusion, 2014, 12(4):533-540. [15] Boesen A P, Hansen R, Boesen M I, et al. Effect of high-volume injection, platelet-rich plasma, and sham treatment in chronic midportion achilles tendinopathy: A randomized double-blinded prospective study[J]. The American Journal of Sports Medicine, 2017, 45(9):2034- 2043. [16] Abate M, Di Carlo L, Salini V. Platelet rich plasma compared to dry needling in the treatment of non- insertional achilles tendinopathy[J]. The Physician and Sportsmedicine, 2019, 47(2):232-237. [17] 巩栋, 赵茂胜, 苏文财, 等. 富血小板血浆治疗兔跟腱病的实验研究[J]. 中国修复重建外科杂志, 2019, 33(7): 871-876. [18] Sconfienza L M, Adriaensen M, Albano D, et al. Clinical indications for image-guided interventional procedures in the musculoskeletal system: A delphi-based consensus paper from the European Society of Musculoskeletal Radiology (ESSR)-part VI, foot and ankle[J]. European Radiology, 2022, 32(2):1384-1394. [19] 张栢毓, 王宁华, Kearney R. 富血小板血浆治疗慢性跟腱病[J]. 中国康复, 2022, 37(1):41. [20] Kearney R S, Ji C, Warwick J, et al. Effect of platelet-rich plasma injection vs sham injection on tendon dysfunction in patients with chronic midportion achilles tendinopathy: A randomized clinical trial[J]. JAMA, 2021, 326(2):137- 144. [21] Chen J G, Wan Y Y, Jiang H Y. The effect of platelet-rich plasma injection on chronic achilles tendinopathy and acute achilles tendon rupture[J]. Platelets, 2022, 33(3): 339-349. [22] Hung C Y, Lin S J, Yeh C Y, et al. Effect of platelet-rich plasma augmentation on endoscopy-assisted percutaneous achilles tendon repair[J]. Journal of Clinical Medicine, 2022, 11(18):5389. [23] Sen I, Kanzafarova I, Yonkus J, et al. Clinical presentation, operative management and long-term outcomes of rupture after previous abdominal aortic aneurysm repair[J]. Journal of Vascular Surgery, 2023, 77(2):396-405. [24] Keene D J, Alsousou J, Harrison P, et al. Platelet-rich plasma injection for acute achilles tendon rupture: Two- year follow-up of the PATH-2 randomized, placebo- controlled, superiority trial[J]. The Bone & Joint Journal, 2022, 104(11):1256-1265. [25] LaBelle M W, Marcus R E. CORR insights?: Is platelet-rich plasma injection effective for chronic achilles tendinopathy? A meta-analysis[J]. Clinical Ortho- paedics and Related Research, 2018, 476(8):1642-1644. [26] Bi Y M, Ehirchiou D, Kilts T M, et al. Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche[J]. Nature Medicine, 2007, 13(10):1219-1227. [27] Kim S J, Oh H W, Chang J W, et al. Recovery of tendon characteristics by inhibition of aberrant differentiation of tendon-derived stem cells from degenerative tendino- pathy[J]. International Journal of Molecular Sciences, 2020, 21(8):2687. [28] Liu C, Li T Y, Chen Y, et al. Tendon microstructural disruption promotes tendon-derived stem cells to express chondrogenic genes by activating endoplasmic reticulum stress[J]. Journal of Orthopaedic Research, 41(2):290-299. [29] Chen J, Zhang E, Zhang W, et al. Fos promotes early stage teno-lineage differentiation of tendon stem/ progenitor cells in tendon[J]. Stem Cells Translational Medicine, 2017, 6(11):2009-2019. [30] Chen Z M, Chen P L, Zheng M, et al. Challenges and perspectives of tendon-derived cell therapy for tendino- pathy: From bench to bedside[J]. Stem Cell Research & Therapy, 2022, 13(1):444. [31] Durgam S S, Stewart A A, Sivaguru M, et al. Tendon-derived progenitor cells improve healing of collagenase-induced flexor tendinitis[J]. Journal of Orthopaedic Research, 2016, 34(12):2162-2171. [32] Komatsu I, Wang J H C, Iwasaki K, et al. The effect of tendon stem/progenitor cell (TSC) sheet on the early tendon healing in a rat achilles tendon injury model[J]. Acta Biomaterialia, 2016, 42:136-146. [33] Chen Z M, Chen P L, Ruan R, et al. Applying a three- dimensional uniaxial mechanical stimulation bioreactor system to induce tenogenic differentiation of tendon- derived stem cells[J]. Journal of Visualized Experiments, 2020(162):e61278. [34] Zhao Z, Liu J Q, Deng Z Q, et al. LncRNA MALAT1 promotes tenogenic differentiation of tendon-derived stem cells via regulating the miR-378a-3p/MAPK1 axis [J]. Bioengineered, 2022, 13(5):13213-13223. [35] Wang J H C, Nirmala X. Application of tendon stem/ progenitor cells and platelet-rich plasma to treat tendon injuries[J]. Operative Techniques in Orthopaedics, 2016, 26(2):68-72. [36] Wei B, Lu J. Characterization of tendon-derived stem cells and rescue tendon injury[J]. Stem Cell Reviews and Reports, 2021, 17(5):1534-1551. [37] Liu C, Luo J W, Zhang K K, et al. Tendon-derived stem cell differentiation in the degenerative tendon microenvi- ronment[J]. Stem Cells International, 2018, 2018:1-12. [38] Li X, Su Z, Shen K, et al. Eugenol-preconditioned mesenchymal stem cell-derived extracellular vesicles promote antioxidant capacity of tendon stem cells in vitro and in vivo[J]. Oxidative Medicine and Cellular Longevity, 2022, 2022:1-20. [39] Mao X F, Yao L W, Li M, et al. Enhancement of tendon repair using tendon-derived stem cells in small intestinal submucosa via M2 macrophage polarization[J]. Cells, 2022, 11(17):2770. [40] Su C A, Jildeh T R, Vopat M L, et al. Current state of platelet-rich plasma and cell-based therapies for the treatment of osteoarthritis and tendon and ligament injuries[J]. The Journal of Bone and Joint Surgery American Volume, 2022, 104(15):1406-1414. [41] Roberts J H, Halper J. Growth factor roles in soft tissue physiology and pathophysiology[J]. Advances in Experi- mental Medicine and Biology, 2021, 1348:139-159. [42] Xu K, Al-Ani M K, Sun Y, et al. Platelet-rich plasma activates tendon-derived stem cells to promote regenera- tion of achilles tendon rupture in rats[J]. Journal of Tissue Engineering and Regenerative Medicine, 2017, 11(4): 1173-1184. [43] Chen L, Liu J P, Tang K L, et al. Tendon derived stem cells promote platelet-rich plasma healing in collagenase- induced rat achilles tendinopathy[J]. Cellular Physiology and Biochemistry, 2014, 34(6):2153-2168. [44] Jo C H, Kim J E, Yoon K S, et al. Platelet-rich plasma stimulates cell proliferation and enhances matrix gene expression and synthesis in tenocytes from human rotator cuff tendons with degenerative tears[J]. The American Journal of Sports Medicine, 2012, 40(5):1035-1045. [45] Tarafder S, Ricupero C, Minhas S, et al. A combination of Oxo-M and 4-PPBP as a potential regenerative thera- peutics for tendon injury[J]. Theranostics, 2019, 9(14): 4241-4254. [46] Zhang Z, Li Y, Zhang T, et al. Hepatocyte growth factor-induced tendon stem cell conditioned medium promotes healing of injured achilles tendon[J]. Frontiers in Cell and Developmental Biology, 2021, 9:654084. [47] 咸杰, 何本祥, 吴骁, 等. 富血小板血浆与肌腱干细胞共混物干预跟腱病模型兔肌腱组织形态及金属蛋白酶1的表达[J]. 中国组织工程研究, 2018, 22(6):921-926. [48] Fedato R A, Francisco J C, Sliva G, et al. Stem cells and platelet-rich plasma enhance the healing process of tendinitis in mice[J]. Stem Cells International, 2019, 2019:1497898. [49] Youngstrom D W, Barrett J G. Engineering tendon: Scaffolds, bioreactors, and models of regeneration[J]. Stem Cells International, 2016, 2016:3919030. [50] 綦惠, 靳少锋, 陈磊, 等. 富血小板血浆复合再生支架修复兔骨软骨缺损[J]. 中国矫形外科杂志, 2018, 26(8): 740-745. [51] 刘继超, 赵金龙, 于洋. 丝素胶原蛋白复合支架联合富血小板血浆修复皮肤损伤[J]. 中国组织工程研究, 2023, 27(25):3971-3976. [52] Zhang J Y, Nie D B, Williamson K, et al. Selectively activated PRP exerts differential effects on tendon stem/progenitor cells and tendon healing[J]. Journal of Tissue Engineering, 2019, 10:20034. |
| 备注/Memo: | 收稿日期:2023-02-28.宁波大学学报（理工版）网址:http://journallg.nbu.edu.cn/ 基金项目:浙江省卫生厅医药卫生项目（2021KY1045）;宁波市科技局重点公益项目（2021S104）;宁波市“科技创新2025”重大专项（2022Z133）;浙江省基础公益研究计划（LBY23H180002）. 第一作者:章松（1997－）,男,浙江宁波人,在读硕士研究生,主要研究方向:足踝外科.E-mail:zhangsong0730@163.com *通信作者:毛海蛟（1979－）,男,浙江宁波人,博士/主任医师,主要研究方向:足踝外科.E-mail:maohaijiao@nbu.edu.cn 宁波大学学报（理工版）网址：http://journallg.nbu.edu.cn/ |
