白色脂肪组织褐变的抗肥胖作用研究进展
PDF下载 (478)陈士勇,王 欣,付建飞,张慧琴,邹祖全,张晓宏*.白色脂肪组织褐变的抗肥胖作用研究进展[J].宁波大学学报(理工版),2013,27(01):119-123.DOI:
CHEN Shi-yong,WANG Xin,FU Jian-fei,ZHANG Hui-qin,ZOU Zu-quan,ZHANG Xiao-hong*.Progress: Anti-obesity Role of White Adipocyte Tissue Browning[J].Journal of Ningbo University(Natural Science & Engineering Edition),2013,27(01):119-123.DOI:
| Title: | Progress: Anti-obesity Role of White Adipocyte Tissue Browning |
| 作者: | 陈士勇, 王 欣, 付建飞, 张慧琴, 邹祖全, 张晓宏* |
| Author(s): | CHEN Shi-yong, WANG Xin, FU Jian-fei, ZHANG Hui-qin, ZOU Zu-quan, ZHANG Xiao-hong* |
| 关键词: | 肥胖; 褐色脂肪组织; 白色脂肪组织; 褐变 |
| Keywords: | obesity; brown adipose tissue; white adipocye tissue; browning |
| 分类号: | Q26; R589.2 |
| 文献标识码: | A |
| 摘要: | 肥胖在发达国家和发展中国家广泛流行, 成为世界性公共卫生问题. 寻找安全、有效的措施拮抗肥胖形成已势在必行. 近年来的研究证实了成年人体内存在功能性褐色脂肪组织, 但是其活性却呈现随年龄增加而递减的趋势. 与褐色脂肪组织不同, 白色脂肪组织人体内分布广泛. 最近的研究证实白色脂肪组织具有很强的可塑性, 在特定情况下能够呈现褐色脂肪表型、获得褐色脂肪的产热活性, 并证实某些信号因子以及某些植物化学物可介导白色脂肪组织褐变. |
| Abstract: | Obesity is a public health problem worldwide, and deserves urgent attention in healthcare sectors. Recent studies show that there are active brown adipose tissues in human adults, but their mass and activities will decrease with aging. In contrast, white adipose tissues are distributed widely in the body. Most importantly, there has been great advancement in studying the function of white adipose tissue. The recent finding suggests that white adipose tissue has strong plasticity, and can get brown phenotype and possess capacity of thermogenesis under some conditions. Besides, some signal factors and phytochemicals are found to be able to mediate the browning of white adipose tissue. In the article, the breakthroughs concerned are reviewed with a view of providing some practical insights for obesity treatment and control |
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| 备注/Memo: | 收稿日期: 2013?04?07. 宁波大学学报（理工版）网址: http://journallg.nbu.edu.cn/基金项目: 国家自然科学基金（30972466, 81172660）; 浙江省自然科学基金（LY12H26001）; 宁波市自然科学基金（2010A610019, 2010A610057）;宁波市领军和拔尖人才培养工程项目; 宁波市科技创新团队（2011B82014）; 浙江省教育厅科研项目（Y200908119）; 宁波大学科研项目（XKl1347）.第一作者: 陈士勇（1986－）, 男, 山东济宁人, 在读硕士研究生, 主要研究方向: 褐色脂肪组织功能与代谢机制. E-mail: chenshiyong0910@163.com*通信作者: 张晓宏（1972－）, 女, 黑龙江哈尔滨人, 博士/教授, 主要研究方向: 代谢病的分子机制. E-mail: zhangxiaohong1@nbu.edu.cn 宁波大学学报（理工版）网址：http://journallg.nbu.edu.cn/ |
