硫硒化镉纳米颗粒对胰高血糖素聚集的影响
PDF下载 (383)李春草1,徐 鹏1,王兰杰1,魏余辉1,孔丽霞1,李 宾2,周星飞1*.硫硒化镉纳米颗粒对胰高血糖素聚集的影响[J].宁波大学学报(理工版),2016,29(1):69-72.DOI:
LI Chun-cao1,XU Peng1,WANG Lan-jie1,WEI Yu-hui1,KONG Li-xia1,LI Bin2,ZHOU Xing-fei1*.Effect of Cadmium Selenide Sulfide Nanoparticles on Glucagon Aggregation[J].Journal of Ningbo University(Natural Science & Engineering Edition),2016,29(1):69-72.DOI:
| Title: | Effect of Cadmium Selenide Sulfide Nanoparticles on Glucagon Aggregation |
| 作者: | 李春草1, 徐 鹏1, 王兰杰1, 魏余辉1, 孔丽霞1, 李 宾2, 周星飞1* |
| Author(s): | LI Chun-cao1, XU Peng1, WANG Lan-jie1, WEI Yu-hui1, KONG Li-xia1, LI Bin2, ZHOU Xing-fei1* |
| 关键词: | 硫硒化镉纳米颗; 胰高血糖素; 原子力显微镜; 纤维化 |
| Keywords: | CdSeS NPs; Glucagon; AFM; Fibrillation |
| 分类号: | O629.8 |
| 文献标识码: | A |
| 摘要: | 利用原子力显微镜、傅里叶变换红外光谱仪和荧光光度计等研究了硫硒化镉纳米颗粒对胰高血糖素聚集的影响, 包括聚集形成纤维数量的多少、纤维的生长速度等. 结果表明: 硫硒化镉纳米颗粒能够抑制胰高血糖素多肽的聚集, 并且随着颗粒浓度的增加, 其抑制胰高血糖素维化的程度也明显加剧. 另外, 还对纳米颗粒抑制胰高血糖素聚集的机理进行了初步讨论. |
| Abstract: | In this paper, we have investigated the effect of Cadmium Selenide Sulfide nanoparticles (CdSeS NPs) on the fibrillation of glucagon peptides using AFM, FTIR and Fluorophotometer. We have found that CdSeS NPs can inhibit glucagon peptide aggregation progress which is strongly dependent on the concentration of CdSeS NPs. In addition, the mechanism of interaction between glucagon and NPs is also discussed. |
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| 备注/Memo: | 收稿日期: 2014?12?17. 宁波大学学报（理工版）网址: http://journallg.nbu.edu.cn/ 基金项目: 国家自然科学基金（ 11474173 ） ; 浙江省自然科学基金（ Y14A040006 ） ; 宁波大学王宽诚教育基金 . 第一作者: 李春草（1987－）, 女, 安徽亳州人, 在读硕士研究生, 主要研究方向: 颗粒对多肽聚集的影响. E-mail: m15257495315@163.com * 通信作者: 周星飞（ 1963 －） , 男 , 浙江余姚人 , 副研究员 , 主要研究方向 : 蛋白分子的自组装 . E-mail: zhouxingfei@nbu.edu.cn 宁波大学学报（理工版）网址：http://journallg.nbu.edu.cn/ |
