宁波市2008~2012年手足口病时空聚集性分析
PDF下载 (26300)张添方 1,刘志芳 1,祝 苗 1,易 波 2,许国章 2,顾 华 3,董长征 1*.宁波市2008~2012年手足口病时空聚集性分析[J].宁波大学学报(理工版),2017,30(3):106-109.DOI:
ZHANG Tian-fang 1,LIU Zhi-fang 1,ZHU Miao 1,YI Bo 2,XU Guo-zhang 2,GU Hua 3,DONG Chang-zheng 1*.Spatial-temporal analysis of hand, foot and mouth disease in Ningbo, 2008-2012[J].Journal of Ningbo University(Natural Science & Engineering Edition),2017,30(3):106-109.DOI:
| Title: | Spatial-temporal analysis of hand, foot and mouth disease in Ningbo, 2008-2012 |
| 作者: | 张添方 1, 刘志芳 1, 祝 苗 1, 易 波 2, 许国章 2, 顾 华 3, 董长征 1* |
| Author(s): | ZHANG Tian-fang 1, LIU Zhi-fang 1, ZHU Miao 1, YI Bo 2, XU Guo-zhang 2, GU Hua 3, DONG Chang-zheng 1* |
| 关键词: | 手足口病; 时空聚集性分析; 空间流行病学 |
| Keywords: | hand, foot and mouth disease (HFMD); spatial-temporal cluster analysis; spatial epidemiology |
| 分类号: | R183 |
| 文献标识码: | A |
| 摘要: | 以街道/镇/乡为基本空间单位, 采用时空扫描统计量对宁波市2008~2012年手足口病的时空聚集性特征进行分析. 结果显示: 2009~2012年宁波均出现了有统计学意义的一级时空聚集区, 聚集区的相对风险介于3.76~5.37, 即聚集区内是聚集区外手足口病发病风险的约3~5倍. 时空聚集性出现的主要区域为宁海和象山的绝大多数街道/镇/乡. 宁海和象山是宁波市手足口病的发病热点地区, 需要采取针对性措施进行重点防控. |
| Abstract: | Surveillance data of hand, foot and mouth disease (HFMD) of Ningbo city during the period of 2008-2012 was analyzed by the spatial-temporal scan statistic. The main purpose of the study was to detect high-incidence clusters and the basic spatial units were sub-district/town/township. The results showed that the most likely clusters with statistical significances occurred in Ningbo annually during the period of 2009-2012. The relative risks ranged from 3.76 to 5.37, which meant the risks of HFMD in these clusters were 3-5 times higher than those out of the clusters. Some sub-districts/towns/townships of Ninghai county and Xiangshan county were the high-incidence clusters of HFMD in Ningbo. In summary, Ninghai county and Xiangshan county were the hot-spots of HFMD epidemics in Ningbo and for the control and prevention of HFMD epidemics. |
| 参考文献 /References: | [1] 桂娟娟, 刘志芳, 华启航, 等. 人肠道病毒71型与手足口病的分子流行病学及其分子进化[J]. 遗传, 2015, 37(5):426-435. [2] MCMINN P C. Recent advances in the molecular epide- miology and control of human enterovirus 71 infection[J]. Current Opinion in Virology, 2012, 2(2):199-205. [3] SOLOMON T, LEWTHWAITE P, PERERA D, et al. Virology, epidemiology, pathogenesis, and control of enterovirus 71[J]. The Lancet Infectious Diseases, 2010, 10(11):778-790. [4] YIP C C Y, LAU S K P, WOO P C Y, et al. Human enterovirus 71 epidemics: What’s next?[EB/OL]. [2016-01-08]. http://www.tandfonline.com/doi/full/10.3402/ehtj.v6i0.19780. [5] ZHANG Y, ZHU Z, YANG W Z, et al. An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of China[EB/OL]. [2015-12-18]. https://virologyj. biomedcentral.com/articles/10.1186/1743-422x-7-94. [6] LI R, LIU L, MO Z, et al. An inactivated enterovirus 71 vaccine in healthy children[J]. New England Journal of Medicine, 2014, 370(9):829-837. [7] LU S. EV71 vaccines: A milestone in the history of global vaccine development[EB/OL]. [2015-12-22]. http://www.nature.com/emi/journal/v3/n4/full/emi201429a.html. [8] ZHU F, XU W, XIA J, et al. Efficacy, safety, and immu- nogenicity of an enterovirus 71 vaccine in China[J]. New England Journal of Medicine, 2014, 370(9):818-828. [9] LIU Y, WANG X, LIU Y, et al. Detecting spatial-temporal clusters of HFMD from 2007 to 2011 in Shandong Province, China[J]. Plos One, 2013, 8(5):e63447. [10] DENG T, YONG H, YU S, et al. Spatial-temporal clusters and risk factors of hand, foot, and mouth disease at the district Level in Guangdong Province, China[J]. Plos One, 2013, 8(2):e56943. [11] GUI J, LIU Z, ZHANG T, et al. Epidemiological charac- teristics and spatial-temporal clusters of hand, foot, and mouth disease in Zhejiang Province, China, 2008-2012[J]. Plos One, 2015, 10(9):e139109. [12] 袁东方, 应莉娅, 董长征. 传染病预警模型研究进展[J]. 浙江预防医学, 2012, 24(8):16-20. [13] 袁东方, 应莉娅, 刘志芳, 等. 基于谷歌地图的传染病空间聚集性分析[J]. 中国卫生统计, 2014, 31(3):414-417. |
| 备注/Memo: | 收稿日期: 2016-04-16. 宁波大学学报(理工版)网址: http://journallg.nbu.edu.cn/ 基金项目: 宁波市自然科学基金(2015A610190); 浙江省教育厅基金(Y201533182); 浙江省重点科技创新团队(2011R50021). 第一作者: 张添方(1990-), 男, 湖北孝感人, 在读硕士研究生, 主要研究方向: 传染病预警模型. E-mail: 564545237@qq.com *通信作者: 董长征(1978-), 男, 浙江丽水人, 博士/副教授, 主要研究方向: 传染病预警模型; 生物信息学. E-mail: dongchangzheng@nbu.edu.cn 宁波大学学报(理工版)网址:http://journallg.nbu.edu.cn/ |