lncRNA在癌细胞生长和代谢中的作用研究进展
PDF下载 (34409)田海华1,2,李静秋1,杨 杰1,龚朝辉1*.lncRNA在癌细胞生长和代谢中的作用研究进展[J].宁波大学学报(理工版),2017,30(6):90-97.DOI:
TIAN Hai-hua1,2,LI Jing-qiu1,YANG Jie1,GONG Zhao-hui1*.Function of long non-coding RNA in cancer cell growth and metabolism[J].Journal of Ningbo University(Natural Science & Engineering Edition),2017,30(6):90-97.DOI:
| Title: | Function of long non-coding RNA in cancer cell growth and metabolism |
| 作者: | 田海华1, 2, 李静秋1, 杨 杰1, 龚朝辉1* |
| Author(s): | TIAN Hai-hua1, 2, LI Jing-qiu1, YANG Jie1, GONG Zhao-hui1* |
| 关键词: | 长链非编码RNA; 细胞周期; 细胞迁移; 肿瘤代谢; 肿瘤标志物 |
| Keywords: | lncRNA; cell cycle; cell migration; tumor metabolism; tumor biomarker |
| 分类号: | A |
| 文献标识码: | A |
| 摘要: | 从长链非编码RNA(long non-coding RNA, lncRNA)与癌细胞生长和代谢的关系角度, 系统地分析和综述了lncRNA如何通过促进或抑制细胞周期进程调节癌细胞生长, lncRNA如何通过调节上皮间质转化影响癌细胞迁移, 以及lncRNA在肿瘤细胞糖类和脂类代谢中如何发挥其作用. |
| Abstract: | Long non-coding RNAs (lncRNAs) are widely found in human cells and involve in vital life processes of gene expression, epigenetic regulation and X-chromosome inactivation. They are suggested to be closely related to tumorigenesis and growth suppression. The review focuses on the role of lncRNA in cancer cell growth and metabolism. A growing body of evidence suggests that lncRNA regulates cancer cell growth by promoting or inhibiting cell cycle. In addition, the review includes how lncRNA affects epithelial-mesenchymal transition (EMT)-mediated cell migration, and how lncRNA functions as a regulator in the glucose and lipid metabolism in tumor cells |
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| 备注/Memo: | 收稿日期: 2016?09?01. 宁波大学学报（理工版）网址: http://journallg.nbu.edu.cn/ 基金项目: 浙江省自然科学基金（LY15C060003）; 宁波市自然科学基金（2015A610220）; 浙江省公益技术研究计划（LGF18H160006）; 宁波大学王宽诚教育基金. 第一作者: 田海华（1982－）, 男, 湖北钟祥人, 在读硕士研究生, 主要研究方向: 肿瘤分子生物学. E-mail: hhtian@ncri.org.cn *通信作者: 龚朝辉（1978－）, 男, 湖北蕲春人, 博士/教授, 主要研究方向: 肿瘤分子生物学. E-mail: zhaohui@ncri.org.cn 宁波大学学报（理工版）网址：http://journallg.nbu.edu.cn/ |
