幽门螺杆菌感染引起非消化系统疾病的研究进展
PDF下载 (354)赵明明,罗 微,谷海瀛.幽门螺杆菌感染引起非消化系统疾病的研究进展[J].宁波大学学报(理工版),2020,33(3):116-120.DOI:
ZHAO Mingming,LUO Wei,GU Haiying.Progress in research of non-digestive diseases caused by Helicobacter pylori infection[J].Journal of Ningbo University(Natural Science & Engineering Edition),2020,33(3):116-120.DOI:
| Title: | Progress in research of non-digestive diseases caused by Helicobacter pylori infection |
| 作者: | 赵明明, 罗 微, 谷海瀛 |
| Author(s): | ZHAO Mingming, LUO Wei, GU Haiying |
| 关键词: | 幽门螺杆菌; 血液系统疾病; 肺炎; 类风湿性关节炎 |
| Keywords: | Helicobactor pylori; hematologic diseases; pneumonia; rheumatoid arthritis |
| 分类号: | R378.99 |
| 文献标识码: | A |
| 摘要: | 幽门螺杆菌是一种革兰氏阴性微需氧型细菌, 可引起消化性溃疡、膜相关淋巴组织淋巴瘤和萎缩性胃炎, 是胃癌的主要诱因. 但近年来, 流行病学调查和动物实验数据提示, 该菌感染与一些非消化系统疾病, 如缺铁性贫血、特发性血小板减少性紫癜、菌血症、肺炎以及类风湿性关节炎等的发生密切相关. 本文就幽门螺杆菌感染引发非消化系统疾病的新进展进行系统剖析, 以期全面展现幽门螺杆菌感染的新领域. |
| Abstract: | Helicobacter pylori, a Gram-negative microaerobic bacteria, is one of the main pathogens causing digestive diseases.In recent years, a growing body of evidence from animal and epidemiological studies shows that the bacterial infection is related to certain non-digestive diseases which include iron-deficiency anemia, idiopathic thrombocytopenic purpura and rheumatoid arthritis. In this article, the latest progress of non-digestive diseases caused by Helicobacter pylori infection was introduced, in order to comprehensively reveal a new field of Helicobacter pylori infection. |
| 参考文献 /References: | [1] Gu H. Role of flagella in the pathogenesis of Helico- bacter pylori[J]. Current Microbiology, 2017, 74(7):863- 869. [2] 毕月, 罗微, 谷海瀛. 幽门螺杆菌致病因子作用机制研究概述[J]. 基础医学与临床, 2018, 38(5):713-716. [3] 王佳静, 谷海瀛. 幽门螺杆菌的基因分型技术及其应用[J]. 浙江大学学报(医学版), 2018, 47(1):97-103. [4] Darvishi M, Ziari K, Mohebbi H, et al. Association between iron deficiency anemia and Helicobacter pylori infection among children under six years in Iran[J]. Acta Medica Iranica, 2015, 53(4):220-224. [5] Hudak L, Jaraisy A, Haj S, et al. An updated systematic review and meta-analysis on the association between Helicobacter pylori infection and iron deficiency anemia[J]. Helicobacter, 2017, 22(1):125-131. [6] Sapmaz F, Basyigit S, Kalkan I H, et al. The impact of Helicobacter pylori eradication on serum hepcidin-25 level and iron parameters in patients with iron deficiency anemia[J]. Wiener Klinische Wochenschrift, 2016, 128(9/ 10):335-340. [7] Nashaat E H, Mansour G M. Helicobacter pylori and anemia with pregnancy[J]. Archives of Gynecology and Obstetrics, 2014, 289(6):1197-1202. [8] el-Said H, Attallah A, Ali-Eldin Z A. Does Helicobacter pylori infection play a role in iron deficiency anemia in hemodialysis patients?[J]. Clinical Nephrology, 2017, 88(10):177-180. [9] Kato S, Osaki T, Kamiya S, et al. Helicobacter pylori sabA gene is associated with iron deficiency anemia in childhood and adolescence[J]. PloS one, 2017, 12(8): e184046. [10] Sheema K, Ikramdin U, Arshi N, et al. Role of Helicobacter pylori eradication therapy on platelet recovery in chronic immune thrombocytopenic purpura [J]. Gastroenterology Research and Practice, 2017, 2017: 1-4. [11] Kikuchi T, Kobayashi T, Yamashita T, et al. Eight-year follow-up of patients with immune thrombocytopenic purpura related to H. pylori infection[J]. Platelets. 2011, 22(1):59-62. [12] Ndawula E M, Owen R J, Mihr G, et al. Helicobacter pylori bacteraemia[J]. European Journal of Clinical Microbiology & Infectious Diseases, 1994, 13(7):621-628. [13] Huang Y, Fan X, Tang Z, et al. Detection of Helicobacter pylori DNA in peripheral blood from patients with peptic ulcer or gastritis.[J]. APMIS, 2006, 114(12):851-856. [14] Han X Y, Tarrand J J, Dickey B F, et al. Helicobacter pylori bacteremia with sepsis syndrome[J]. Journal of Clinical Microbiology, 2010, 48(12):4661-4663. [15] Nakashima S, Kakugawa T, Yura H, et al. Identification of Helicobacter pylori VacA in human lung and its effects on lung cells[J]. Biochemical and Biophysical Research Communications, 2015, 460(3):721-726. [16] Ebrahimi A, Soofizadeh B, Ebrahimi F, et al. Relationship between Helicobacter pylori cytotoxin-associated gene A protein with clinical outcomes in patients with rheumatoid arthritis[J]. Immunology Letters, 2019, 211:49-52. [17] Zentilin P, Seriolo B, Dulbecco P, et al. Eradication of Helicobacter pylori may reduce disease severity in rheumatoid arthritis[J]. Alimentary Pharmacology and Therapeutics, 2002, 16(7):1291-1299. [18] Hasni S, Ippolito A, Illei G G. Helicobacter pylori and autoimmune diseases[J]. Oral Diseases. 2011, 17(7):621- 627. [19] Bartels L E, Pedersen A B, Kristensen N R, et al. Helicobacter pylori infection is not associated with rheumatoid arthritis[J]. Scandinavian Journal of Rheumatology, 2019, 48(1):24-31. [20] Beckett A C, Piazuelo M B, Noto J M, et al. Dietary composition influences incidence of Helicobacter pylori: Induced iron deficiency anemia and gastric ulceration[J]. Infection and Immunity, 2016, 84(12):3338-3349. [21] Noto J M, Gaddy J A, Lee J Y, et al. Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans[J]. The Journal of Clinical Investigation, 2013, 123(1):479-492. [22] Gaddy J A, Radin J N, Loh J T, et al. High dietary salt intake exacerbates Helicobacter pylori-induced gastric carcinogenesis[J]. Infection and Immunity, 2013, 81(6): 2258-2267. [23] Xie C, Xu L, Li W, et al. Helicobacter pylori infection in Mongolian gerbils does not initiate hematological diseases[J]. World Journal of Gastroenterology, 2014, 20(34): 12308-12312. [24] Burns M, Muthupalani S, Ge Z, et al. Helicobacter pylori infection induces anemia, depletes serum iron storage, and alters local iron-related and adult brain gene expression in male INS-GAS mice[J]. PLoS One, 2015, 10(11):e142630. [25] Kim B J, Kim H S, Jang H J, et al. Helicobacter pylori eradication in idiopathic thrombocytopenic purpura: A meta-analysis of randomized trials[J]. Gastroenterology Research and Practice, 2018, 2018:1-8. [26] Takahashi T, Yujiri T, Shinohara K, et al. Molecular mimicry by Helicobacter pylori CagA protein may be involved in the pathogenesis of H. pylori-associated chronic idiopathic thrombocytopenic purpura[J]. British Journal of Haematology, 2004, 124(1):91-96. [27] Bai Y, Wang Z, Bai X, et al. Cross-reaction of antibody against Helicobacter pylori urease B with platelet glycoprotein IIIa and its significance in the pathogenesis of immune thrombocytopenic purpura[J]. International Journal of Hematology, 2009, 89(2):142-149. [28] Gravina A G, Zagari R M, De Musis C, et al. Helicobacter pylori and extragastric diseases: A review[J]. World Journal of Gastroenterology. 2018, 24(29):3204- 3221. [29] Satoh K, Hirayama T, Takano K, et al. VacA, the vacuolating cytotoxin of Helicobacter pylori, binds to multimerin 1 on human platelets[J]. Thrombosis Journal, 2013, 11(1):23-29. [30] Fukuda T, Asou E, Nogi K, et al. Association between Helicobacter pylori infection and platelet count in mice[J]. Experimental Animals, 2018, 67(4):487-492. [31] Ridgley L A, Anderson A E, Pratt A G. What are the dominant cytokines in early rheumatoid arthritis?[J]. Current Opinion in Rheumatology, 2018, 30(2):207-214. [32] Yamanishi S, Iizumi T, Watanabe E, et al. Implications for induction of autoimmunity via activation of B-1 cells by Helicobacter pylori urease[J]. Infection and Immunity, 2006, 74(1):248-256. [33] Magen E, Delgado J. Helicobacter pylori and skin autoimmune diseases[J]. World Journal of Gastroentero- logy, 2014, 20(6):1510-1516. [34] 沈俊, 吴秋惠, 陈燕华, 等. 益生菌用于幽门螺杆菌感染治疗的研究进展[J]. 中国医院药学杂志, 2019, 39(22): 2351-2356. |
| 备注/Memo: | 收稿日期:2019-12-16.宁波大学学报(理工版)网址:http://journallg.nbu.edu.cn/ 基金项目:浙江省自然科学基金重点项目(LZ14H200001). 第一作者:赵明明(1996-),女,吉林四平人,在读硕士研究生,主要研究方向:临床微生物学.E-mail:295387949@qq.com *通信作者:谷海瀛(1966-),男,吉林长春人,博士/教授,主要研究方向:临床微生物学.E-mail:guhaiying@nbu.edu.cn 宁波大学学报(理工版)网址:http://journallg.nbu.edu.cn/ |