幽门螺杆菌感染小鼠模型的应用进展
PDF下载 (2270)朱 媚,马郁荃,谷海瀛.幽门螺杆菌感染小鼠模型的应用进展[J].宁波大学学报(理工版),2021,34(3):91-95.DOI:
ZHU Mei,MA Yuquan,GU Haiying.Progress in application of mouse models of Helicobacter pylori infection[J].Journal of Ningbo University(Natural Science & Engineering Edition),2021,34(3):91-95.DOI:
| Title: | Progress in application of mouse models of Helicobacter pylori infection |
| 作者: | 朱 媚, 马郁荃, 谷海瀛 |
| Author(s): | ZHU Mei, MA Yuquan, GU Haiying |
| 关键词: | 幽门螺杆菌; 动物模型; 小鼠; 胃炎; 胃癌 |
| Keywords: | Helicobacter pylori; animal models; mice; gastritis; gastric cancer |
| 分类号: | R378.99 |
| 文献标识码: | A |
| 摘要: | 幽门螺杆菌动物模型是幽门螺杆菌感染导致人类胃炎、消化性溃疡、胃癌等致病机制研究的基础, 也是幽门螺杆菌感染和胃肠外疾病相关性研究的重要工具. 近年来幽门螺杆菌感染动物模型得到了广泛的应用和发展, 制备感染模型常用的动物有小鼠、蒙古沙鼠、豚鼠、悉生乳猪和恒河猴等, 其中幽门螺杆菌悉尼菌株感染的小鼠模型使用最广泛. 本文对幽门螺杆菌感染小鼠模型应用的最新进展做一综述. |
| Abstract: | Animal models of Helicobacter pylori are the basis for the study of pathogenic mechanisms of Helicobacter pylori infection in humans such as gastritis, peptic ulcer, and gastric cancer. They are also important tools for studying the correlation between Helicobacter pylori infection and extra gastric diseases. In recent years, animal models of Helicobacter pylori infection have been widely used and developed. The commonly used animals for infection models include mice, Mongolian gerbils, guinea pigs, gnotobiotic piglets and rhesus monkeys. Mice infected with Helicobacter pylori Sydney Strain are the most widely used models among them. In this article, the latest progress in the application of mouse models is reviewed. |
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| 备注/Memo: | 收稿日期:2020-12-06.宁波大学学报（理工版）网址:http://journallg.nbu.edu.cn/ 基金项目:浙江省自然科学基金重点项目（LZ14H200001）. 第一作者:朱媚（1979－）,女,湖北石首人,在读硕士研究生,主要研究方向:临床检验诊断学.E-mail:364846095@qq.com *通信作者:谷海瀛（1966－）,男,吉林长春人,博士/教授,主要研究方向:临床微生物学.E-mail:guhaiying@nbu.edu.cn 宁波大学学报（理工版）网址：http://journallg.nbu.edu.cn/ |
