食管癌根治术后严重并发症对患者短期生存的影响
PDF下载 (193)林城斌,沈韦羽.食管癌根治术后严重并发症对患者短期生存的影响[J].宁波大学学报(理工版),2022,35(3):76-80.DOI:
LIN Chengbin,SHEN Weiyu.Impact of major morbidity following esophageal cancer radical resection on short-term patient survival[J].Journal of Ningbo University(Natural Science & Engineering Edition),2022,35(3):76-80.DOI:
| Title: | Impact of major morbidity following esophageal cancer radical resection on short-term patient survival |
| 作者: | 林城斌, 沈韦羽 |
| Author(s): | LIN Chengbin, SHEN Weiyu |
| 关键词: | 食管癌; 食管切除术; 严重并发症; 短期生存 |
| Keywords: | esophageal carcinoma; esophagectomy; severe complications; short-term survival |
| 分类号: | R655.4 |
| 文献标识码: | A |
| 摘要: | 为了探讨食管癌根治术后严重并发症对患者短期生存的影响, 选取2015年11月至2018年12月期间在宁波大学附属李惠利医院行食管癌根治术后的患者符合本研究入组条件的临床病理资料进行统计分析. 单因素分析结果表明 术前合并肺部疾病、糖尿病、术后出现严重并发症3个因素与食管癌根治术后短期生存相关(P<0.05). 多因素分析结果表明 术后出现严重并发症是影响术后短期生存的独立预测因素(P<0.05). 将149例患者按术后是否有严重并发症分为有严重并发症组和无并发症组进行随访, 通过绘制生存曲线得出无并发症组的短期生存率高于有严重并发症组的短期生存率. |
| Abstract: | The current study is designed to investigate the effect of severe complications on short-term survival following radical resection of esophageal carcinoma, based on the clinicopathologic data of the patients who underwent radical esophagectomy from November 2015 till December 2018 in the Affiliated Lihuili Hospital of Ningbo University. The results of univariate analysis showed that pre-operative lung disease, diabetes mellitus and severe postoperative complications were all associated with short-term survival (P<0.05). Multivariate analysis showed that severe postoperative complications were independent predictors of short-term survival (P<0.05). A total of 149 patients were divided into the severe complications group and no complications group, based on the occurrence of serious complications following operation. The severe complications group and the no complications group were followed up and survival curve analysis was performed. The short-term survival rate of the severe complications group was significantly higher than that of no complications group. Comparison of the survival curves of patients between with and without serious complications suggested that the short-term survival of the patients was affected by severe complications. |
| 参考文献 /References: | [1] Sung H, Ferlay J, Siegel R L, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA: A Cancer Journal for Clinicians, 2021, 71(3):209-249. [2] Bhayani N H, Gupta A, Dunst C M, et al. Esophagectomies with thoracic incisions carry increased pulmonary morbidity[J]. JAMA Surgery, 2013, 148(8): 733-738. [3] Blencowe N S, Strong S, McNair A G K, et al. Reporting of short-term clinical outcomes after esophagectomy: A systematic review[J]. Annals of Surgery, 2012, 255(4): 658-666. [4] Schlottmann F, Patti M G. Prevention of postoperative pulmonary complications after esophageal cancer surgery [J]. Journal of Thoracic Disease, 2019, 11(S9):S1143- S1144. [5] Kataoka K, Takeuchi H, Mizusawa J, et al. Prognostic impact of postoperative morbidity after esophagectomy for esophageal cancer: Exploratory analysis of JCOG9907[J]. Annals of Surgery, 2017, 265(6):1152-1157. [6] Badgwell B, Ajani J, Blum M, et al. Postoperative morbidity and mortality rates are not increased for patients with gastric and gastroesophageal cancer who undergo preoperative chemoradiation therapy[J]. Annals of Surgical Oncology, 2016, 23(1):156-162. [7] Nishikawa K, Fujita T, Yuda M, et al. Early postoperative endoscopy for targeted management of patients at risks of anastomotic complications after esophagectomy[J]. Surgery, 2016, 160(5):1294-1301. [8] Ohi M, Toiyama Y, Omura Y, et al. Risk factors and measures of pulmonary complications after thoracoscopic esophagectomy for esophageal cancer[J]. Surgery Today, 2019, 49(2):176-186. [9] Low D E, Alderson D, Cecconello I, et al. International consensus on standardization of data collection for com- plications associated with esophagectomy: Esophagectomy complications consensus group (ECCG)[J]. Annals of Surgery, 2015, 262(2):286-294. [10] 许庆生, 支修益, 张毅, 等. 75岁以上高龄食管、贲门癌患者的外科治疗[J]. 中国胸心血管外科临床杂志, 2009, 16(3):237-239. [11] Zheng X, Ma X S, Deng H Y, et al. Diabetes mellitus and survival of esophageal cancer patients after esophagectomy: A systematic review and meta-analysis[J]. Diseases of the Esophagus, 2020, 33(2):doz098. [12] Gómez-Caro A, Moradiellos F J, Ausín P, et al. Risk factors for atrial fibrillation after thoracic surgery[J]. Archivos De Bronconeumología (English Edition), 2006, 42(1):9-13. [13] Dindo D, Demartines N, Clavien P A. Classification of surgical complications: A new proposal with evaluation in a cohort of 6336 patients and results of a survey[J]. Annals of Surgery, 2004, 240(2):205-213. [14] Lagarde S M, Reitsma J B, Maris A K D, et al. Preoperative prediction of the occurrence and severity of complications after esophagectomy for cancer with use of a nomogram[J]. The Annals of Thoracic Surgery, 2008, 85(6):1938-1945. [15] Siegel R L, Miller K D, Jemal A. Cancer statistics, 2015[J]. CA: A Cancer Journal for Clinicians, 2015, 65(1):5-29. [16] Lin Y S, Totsuka Y, He Y T, et al. Epidemiology of esophageal cancer in Japan and China[J]. Journal of Epidemiology, 2013, 23(4):233-242. [17] Huang F L, Yu S J. Esophageal cancer: Risk factors, genetic association, and treatment[J]. Asian Journal of Surgery, 2018, 41(3):210-215. [18] Chen W Q, Zheng R S, Baade P D, et al. Cancer statistics in China, 2015[J]. CA: A Cancer Journal for Clinicians, 2016, 66(2):115-132. [19] Ruteg?rd M, Lagergren P, Rouvelas I, et al. Intrathoracic anastomotic leakage and mortality after esophageal cancer resection: A population-based study[J]. Annals of Surgical Oncology, 2012, 19(1):99-103. [20] Mlecnik B, Bindea G, Pagès F, et al. Tumor immunosurveillance in human cancers[J]. Cancer Metastasis Reviews, 2011, 30(1):5-12. [21] Grotenhuis B A, Wijnhoven B P L, Grüne F, et al. Preoperative risk assessment and prevention of complications in patients with esophageal cancer[J]. Journal of Surgical Oncology, 2010, 101(3):270-278. [22] Chin J H, Moon Y J, Jo J Y, et al. Association between postoperatively developed atrial fibrillation and long-term mortality after esophagectomy in esophageal cancer patients: An observational study[J]. PLoS One, 2016, 11(5):e0154931. [23] Aoyama T, Kazama K, Atsumi Y, et al. Clinical influence of anastomotic leakage on esophageal cancer survival and recurrence[J]. Anticancer Research, 2020, 40(1):443-449. [24] Markar S, Gronnier C, Duhamel A, et al. The impact of severe anastomotic leak on long-term survival and cancer recurrence after surgical resection for esophageal malignancy[J]. Annals of Surgery, 2015, 262(6):972-980. [25] 邱龙, 李向楠, 赵松, 等. 食管癌术后颈部食管胃吻合口瘘的危险因素分析[J]. 中华消化外科杂志, 2017, 16(5):483-489. [26] Tamagawa A, Aoyama T, Tamagawa H, et al. Influence of postoperative pneumonia on esophageal cancer survival and recurrence[J]. Anticancer Research, 2019, 39(5): 2671-2678. [27] Booka E, Takeuchi H, Nishi T, et al. The impact of postoperative complications on survivals after esophagectomy for esophageal cancer[J]. Medicine, 2015, 94(33):e1369. |
| 备注/Memo: | 收稿日期:2021-10-18.宁波大学学报（理工版）网址:http://journallg.nbu.edu.cn/ 第一作者:林城斌（1995－）,男,浙江宁波人,在读硕士研究生,主要研究方向:心胸外科.E-mail:linchengbin88752@163.com *通信作者:沈韦羽（1964－）,男,浙江宁波人,教授,主要研究方向:心胸外科.E-mail:shenweiyu@nbu.edu.cn 宁波大学学报（理工版）网址：http://journallg.nbu.edu.cn/ |
