α-环香叶酸的合成工艺研究
PDF下载 (401)胡艳华,江峰,赵洋洋,张剑锋*.α-环香叶酸的合成工艺研究[J].宁波大学学报(理工版),2016,29(1):73-76.DOI:
HU Yan-hua,JIANG Feng,ZHAO Yang-yang,ZHANG Jian-feng*.Synthesis and Process of the -cyclogeranic Acid: Research[J].Journal of Ningbo University(Natural Science & Engineering Edition),2016,29(1):73-76.DOI:
| Title: | Synthesis and Process of the -cyclogeranic Acid: Research |
| 作者: | 胡艳华, 江峰, 赵洋洋, 张剑锋* |
| Author(s): | HU Yan-hua, JIANG Feng, ZHAO Yang-yang, ZHANG Jian-feng* |
| 关键词: | α-环香叶酸; 柠檬醛; 氧化; 关环 |
| Keywords: | -cyclogeranic acid; citral; oxidation; cyclization |
| 分类号: | O622.5 |
| 文献标识码: | A |
| 摘要: | α-环香叶酸是合成大马酮类香料的关键中间体, 比较了现有的几种α-环香叶酸的合成方法, 选择和确认了一条以柠檬醛为原料, 经氧化关环得到α-环香叶酸的合成工艺, 其合成的α-环香叶酸纯度可达到96.6%, 总产率为65.3%. 该合成方法具有反应条件温和、总产率较高的优点, 适合工业化生产. |
| Abstract: | α-cyclogeranic acid is a key intermediate of the damascones. Based on comparison of several synthetic methods in the literatures, α-cyclogeranic acid is synthesized from citral through oxidation and cyclization. This synthetic method has advantages such as mild conditions and high yield, the yield of the α-cyclogeranic acid can be as high as 65.3%, and the purity of the product can reach as high as 96.6%. This method is found to be suitable for industrial production |
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| 备注/Memo: | 收稿日期: 2014?11?17. 宁波大学学报（理工版）网址: http://journallg.nbu.edu.cn/ 基金项目: 宁波市自然科学基金（2012A610086）, 宁波大学创新开放实验项目（cxxkf201415）; 宁波大学研究生教育改革项目（JGZDI201302）. 第一作者: 胡艳华（1991－）, 女, 江西鄱阳人, 在读硕士研究生, 主要研究方向: 有机合成及催化. E-mail: huyanhua1124@126.com *通信作者: 张剑锋（1968－）, 男, 湖南邵阳人, 博士/副教授, 主要研究方向: 合成化学. E-mail: zjf@nbu.edu.cn 宁波大学学报（理工版）网址：http://journallg.nbu.edu.cn/ |
