环状RNA在内分泌与代谢疾病中的研究进展
PDF下载 (424)严海燕1,习 阳2,麦一峰1*.环状RNA在内分泌与代谢疾病中的研究进展[J].宁波大学学报(理工版),2018,31(6):115-120.DOI:
YAN Hai-yan1,XI Yang2,MAI Yi-feng1*.The role of circRNAs in endocrine and metabolic diseases[J].Journal of Ningbo University(Natural Science & Engineering Edition),2018,31(6):115-120.DOI:
| Title: | The role of circRNAs in endocrine and metabolic diseases |
| 作者: | 严海燕1, 习 阳2, 麦一峰1* |
| Author(s): | YAN Hai-yan1, XI Yang2, MAI Yi-feng1* |
| 关键词: | 环状RNA; 非编码RNA; 内分泌与代谢疾病; 生物标志物 |
| Keywords: | circRNA; non-coding RNA; endocrine and metabolic disease; biomarker |
| 分类号: | R58 |
| 文献标识码: | A |
| 摘要: | 环状RNA是一种新兴的具有闭合环状结构的内源性非编码RNA, 主要由前体RNA通过可变剪切加工形成的闭合环状RNA分子, 不具有5’端帽子和3’端polyA尾巴结构. 目前研究认为环状RNA具有丰度显著增高、结构稳定、发育阶段特异性表达和物种间保守性等特征, 说明circRNA在基因表达方面有重要的调控作用. 近年来, 研究发现circRNA在肿瘤、糖尿病、非酒精性脂肪肝、心血管系统疾病以及神经紊乱等疾病的发生发展中起着重要的作用, 尤其在内分泌与代谢疾病的发生发展中扮演了重要角色. 因此环状RNA作为新的生物标志物, 为疾病的诊断和治疗提供了新的思路. 本文对环状RNA的结构功能与内分泌代谢疾病的关联以及其潜在临床价值进行了综述. |
| Abstract: | circRNA is an emerging endogenous noncoding RNA with a closed ring structure. A closed circular RNA molecule, which is mainly composed of precursor RNA through variable shear processing, does not have a 5’ end cap and 3’ end poly A tail structure. The circular RNA has a significantly higher abundance, stable structure, specific expression of developmental stages and conservative characteristics between species. It indicates that circRNAs play an important role in regulating gene expression. In recent years, emerging evidences indicate that circRNAs involve in a wide range of diseases, including cancer, diabetes, non-alcoholic fatty hepatitis, cardiovascular system diseases and neurological disorders. As a new biomarker, circRNAs provide a new approach for the diagnosis and treatment of diseases. This paper reviews the structure function of circRNAs, the association with endocrine metabolic diseases and the potential clinical value. |
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| 备注/Memo: | 收稿日期: 2018?03?28. 宁波大学学报（理工版）网址: http://journallg.nbu.edu.cn/ 基金项目: 国家自然科学基金（81700436）. 第一作者: 严海燕（1982－）, 女, 浙江宁波人, 主治医师, 主要研究方向: 内分泌与代谢. E-mail: viven_yan0627@sina.cn *通信作者: 麦一峰（1963－）, 男, 浙江宁波人, 主任医师, 主要研究方向: 内分泌与心血管. E-mail: 27544559@qq.com 宁波大学学报（理工版）网址：http://journallg.nbu.edu.cn/ |
