水生生物卵黄蛋白原在内分泌干扰物检测中的应用
PDF下载 (503)顾海龙,陈彩芳,林志华,霍礼辉.水生生物卵黄蛋白原在内分泌干扰物检测中的应用[J].宁波大学学报(理工版),2013,26(02):12-16.DOI:
GU Hai-long,CHEN Cai-fang,LIN Zhi-hua,HUO Li-hui.The Vitellogenin Application of Aquatic Organisms in Detecting Endocrine Disrupting Chemicals[J].Journal of Ningbo University(Natural Science & Engineering Edition),2013,26(02):12-16.DOI:
| Title: | The Vitellogenin Application of Aquatic Organisms in Detecting Endocrine Disrupting Chemicals |
| 作者: | 顾海龙, 陈彩芳, 林志华, 霍礼辉 |
| Author(s): | GU Hai-long, CHEN Cai-fang, LIN Zhi-hua, HUO Li-hui |
| 关键词: | 卵黄蛋白原; 环境雌激素; 内分泌干扰物; 生物标志物 |
| Keywords: | vitellogenin; environmental estrogens; endocrine disrupting chemicals; biomarker |
| 分类号: | X835 |
| 文献标识码: | A |
| 摘要: | 卵黄蛋白原(Vitellogenin, Vg)作为卵生脊椎、无脊椎动物的卵黄蛋白前体, 是在激素的严格调控下合成的一种雌性特异性蛋白, 因具有广谱性、灵敏度高等优点, Vg成为目前监测水环境中内分泌干扰物的良好生物标志物之一. 然而, 水环境中的内分泌干扰物复杂多样, 诱导能力也随环境的不同而效果不一. 因此, Vg作为生物标志物在实际应用中面临巨大挑战. 笔者主要对水生生物Vg在内分泌干扰物检测中的应用进行归纳总结, 并对今后Vg的研究方向及研究重点进行展望, 以期为Vg作为生物标志物的研究提供参考和借鉴. |
| Abstract: | Vitellogenin is the major precursor of the egg-yolk proteins, vitellin. It is a female-specific protein which is synthesized under the strict regulation of the hormone. With the advantages of broad-spectrum and high sensitivity, Vg is a good biomarker for the monitoring of endocrine disrupting chemicals. However, the endocrine disruptors in the water are complex and diverse, and their induced effects vary according to the environment. Therefore, Vg in practical applications is facing enormous challenges to function as a biomarker. In this article, the Vitellogenin application of aquatic organisms in detecting endocrine disrupting chemicals is addressed in an effort to provide a reference for the study on Vg as a biomarker. |
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| 备注/Memo: | 收稿日期: 2012－12－26. 基金项目: 国家科技支撑计划（2009BADB7B02）; 国家贝类产业技术体系（CARS-48）; 宁波市自然科学基金（2011A610016）. 第一作者: 顾海龙（1988－）, 男, 江苏靖江人, 在读硕士研究生, 主要研究方向: 海洋贝类养殖生物学. E-mail: ghl2006-happy@163.com *通信作者: 陈彩芳（1982－）, 女, 浙江临海人, 讲师, 主要研究方向: 海洋贝类环境生物学. E-mail: chencaifang@zwu.edu.cn 宁波大学学报（理工版）网址：http://journallg.nbu.edu.cn/ |
