单球壳模型参数对细胞介电频谱的影响
PDF下载 (483)廖 聪 1,吴佳瑛 2,孙梦霞 1,岑莉超 1,马 青 1*.单球壳模型参数对细胞介电频谱的影响[J].宁波大学学报(理工版),2018,31(1):99-104.DOI:
LIAO Cong 1,WU Jia-ying 2,SUN Meng-xia 1,CEN Li-chao 1,MA Qing 1*.Influence of single shell model parameters on cellular dielectric spectra[J].Journal of Ningbo University(Natural Science & Engineering Edition),2018,31(1):99-104.DOI:
| Title: | Influence of single shell model parameters on cellular dielectric spectra |
| 作者: | 廖 聪 1, 吴佳瑛 2, 孙梦霞 1, 岑莉超 1, 马 青 1* |
| Author(s): | LIAO Cong 1, WU Jia-ying 2, SUN Meng-xia 1, CEN Li-chao 1, MA Qing 1* |
| 关键词: | 单球壳模型; 介电频谱; 介电常数; 电导率; 复平面图 |
| Keywords: | single spherical shell model; dielectric spectrum; permitivity; conductivity; complex plane plot |
| 分类号: | Q64 |
| 文献标识码: | A |
| 摘要: | 为研究单球壳模型的9个参数(εo, κo, εm, κm, εin, κin, R, d, Φ)对细胞介电频谱的影响, 采用固定其他8个参数, 仅改变单一参数的方法, 观察介电频谱的变化. 结果表明: εo主要影响低频和高频介电常数(εl和εh); κo主要影响低频和高频电导率(κl和κh); εm主要影响低频介电常数(εl)、介电增量(Δε)和特征频率(fc); κm主要影响低频参数(εl, κh)和增量(Δε, Δκ); εin主要影响高频电导率(κh); κin主要影响高频电导率(κh)、电导率增量(Δκ)和特征频率(fc); R和d主要影响εl、Δε和fc, 但两者作用相反; 体积分数Φ主要影响低频参数(εl, κl)和增量(Δε, Δκ)以及κh. 阐明单球壳细胞模型的参数变化规律, 有益于提取细胞电学参数(细胞膜和细胞质), 为探讨癌变细胞的电生理机制提供帮助. |
| Abstract: | In order to investigate the effect of nine parameters (εo, κo, εm, κm, εin, κin, R, d, Φ) of the single spherical model on the dielectric spectrum of cell, we used the method of observing the changing behaviors of dielectric spectrum with eight parameters fixed and only one parameter variable. The results show that the parameter εo mainly affects the low frequency and high frequency permittivity (εl, εh). κo mainly affects the low frequency and high frequency conductivity (κl, κh). εm mainly affects the low frequency permittivity (εl), the permittivity increment (Δε) and the characteristic frequency (fc); κm mainly affects the low frequency parameters (εl, κh) and the increment (Δε, Δκ); εin mainly affect (κh), κin mainly affect the high frequency conductivity(κh), conductivity increment (Δκ) and characteristic frequency (fc); R and d mainly affect εl , Δε and fc, but the effect is opposite between the two parameters; volume fraction Φ mainly effects the low frequency parameters (εl, κl) and increment (Δε, Δκ) and κh. The rules of parametric variation of the single spherical shell cell model are elucidated, which is beneficial to extract the electrical parameters (cell membrane and cytoplasm), and to explore the electrophysiological mechanism of the cancerous cells. |
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| 备注/Memo: | 收稿日期: 2017－06－21. 宁波大学学报（理工版）网址: http://journallg.nbu.edu.cn/基金项目: 国家自然科学基金（51277099）; 宁波市科技惠民项目（2015C50009）.第一作者: 廖聪（1993－）, 女, 湖北鄂州人, 在读硕士研究生, 主要研究方向: 细胞介电频谱的理论分析. E-mail: 786484089@qq.com*通信作者: 马青（1962－）, 男, 黑龙江佳木斯人, 教授, 主要研究方向: 细胞生物物理. E-mail: maqing@nbu.edu.cn 宁波大学学报（理工版）网址：http://journallg.nbu.edu.cn/ |
