生物可降解镁合金骨科植入材料的临床应用及其有限元分析
PDF下载 (340)张雁儒,刘莹莹.生物可降解镁合金骨科植入材料的临床应用及其有限元分析[J].宁波大学学报(理工版),2022,35(1):1-6.DOI:
ZHANG Yanru,LIU Yingying.Clinical application and finite element analysis of biodegradable magnesium alloy orthopedic implants[J].Journal of Ningbo University(Natural Science & Engineering Edition),2022,35(1):1-6.DOI:
| Title: | Clinical application and finite element analysis of biodegradable magnesium alloy orthopedic implants |
| 作者: | 张雁儒, 刘莹莹 |
| Author(s): | ZHANG Yanru, LIU Yingying |
| 关键词: | 生物可降解镁合金; 骨科植入材料; 临床应用; 有限元分析 |
| Keywords: | biodegradable magnesium alloy; orthopedic implant material; clinical application; finite element analysis |
| 分类号: | R608 |
| 文献标识码: | A |
| 摘要: | 在骨-器械界面建立和维持成熟骨是骨科植入材料长期成功的关键. 镁合金由于其生物可降解性、天然骨组织的力学相似性以及成骨潜力, 并且在体内不抑制间充质干细胞(hBMSCs)的成骨特性, 成为有前途的承重骨科植入物的候选材料. 但其高降解率和植入物相关感染的风险以及不佳的力学性能, 对其临床应用提出了巨大的挑战. 有限元分析方法能对复杂结构、形态、载荷和材料力学性能进行应力分析, 可有效地帮助临床医生了解镁合金植入器械的应力及生物力学性能. |
| Abstract: | The establishment and maintenance of mature bone at the bone-device interface are critical to the long-term success of orthopedic implant materials. Magnesium alloys are promising candidate materials for weight-bearing orthopedic implants because of their biodegradability, mechanical similarity to natural bone tissue, osteogenic potential, and non-inhibition of the osteogenic properties of human bone mesenchymal stem cells (hBMSCs) in vivo. However, the high degradation rate, the risk of implant-related infection and poor mechanical properties pose great challenges to their clinical application. The finite element analysis method can analyze the stress of complex structure, shape, load and mechanical properties of materials, and can effectively help clinicians understand the stress and biomechanical properties of magnesium alloy implanted devices. |
| 参考文献 /References: | [1] Zhang F, Xu H, Wang H, et al. Quantitative analysis of near-implant magnesium accumulation for a Si-containing coated AZ31 cage from a goat cervical spine fusion model[J]. BMC Musculoskeletal Disorders, 2018, 19(1):105. [2] Wang J L, Mukherjee S, Nisbet D R, et al. In vitro evaluation of biodegradable magnesium alloys containing micro-alloying additions of strontium, with and without zinc[J]. Journal of Materials Chemistry B, 2015, 3(45):8874-8883. [3] Witte F, Ulrich H, Palm C, et al. Biodegradable magnesium scaffolds: Part II: Peri-implant bone remodeling[J]. Journal of Biomedical Materials Research Part A, 2007, 81A(3):757-765. [4] Zhen Z, Luthringer B, Yang L, et al. Proteomic profile of mouse fibroblasts exposed to pure magnesium extract[J]. Materials Science and Engineering: C, 2016, 69:522-531. [5] Zhang X Z, Zu H Y, Zhao D W, et al. Ion channel functional protein kinase TRPM7 regulates Mg ions to promote the osteoinduction of human osteoblast via PI3K pathway: In vitro simulation of the bone-repairing effect of Mg-based alloy implant[J]. Acta Biomaterialia, 2017, 63:369-382. [6] Zreiqat H, Valenzuela S M, Nissan B B, et al. The effect of surface chemistry modification of titanium alloy on signalling pathways in human osteoblasts[J]. Biomaterials, 2005, 26(36):7579-7586. [7] Yoshizawa S, Brown A, Barchowsky A, et al. Magnesium ion stimulation of bone marrow stromal cells enhances osteogenic activity, simulating the effect of magnesium alloy degradation[J]. Acta Biomaterialia, 2014, 10(6):2834-2842. [8] Wang Y, Geng Z, Huang Y C, et al. Unraveling the osteogenesis of magnesium by the activity of osteoblasts in vitro[J]. Journal of Materials Chemistry B, 2018, 6(41):6615-6621. [9] Witte F, Kaese V, Haferkamp H, et al. In vivo corrosion of four magnesium alloys and the associated bone response[J]. Biomaterials, 2005, 26(17):3557-3563. [10] Yoshizawa S, Chaya A, Verdelis K, et al. An in vivo model to assess magnesium alloys and their biological effect on human bone marrow stromal cells[J]. Acta Biomaterialia, 2015, 28:234-239. [11] Xiong P, Jia Z J, Zhou W H, et al. Osteogenic and pH stimuli-responsive self-healing coating on biomedical Mg-1Ca alloy[J]. Acta Biomaterialia, 2019, 92:336-350. [12] You M Y, Echeverry-Rendón M, Zhang L, et al. Effects of composition and hierarchical structures of calcium phosphate coating on the corrosion resistance and osteoblast compatibility of Mg alloys[J]. Materials Science and Engineering: C, 2021, 120:111734. [13] Torroni A, Xiang C C, Witek L, et al. Biocompatibility and degradation properties of WE43 Mg alloys with and without heat treatment: In vivo evaluation and comparison in a cranial bone sheep model[J]. Journal of Cranio-Maxillofacial Surgery, 2017, 45(12):2075-2083. [14] Yang C X, Yuan G Y, Zhang J, et al. Effects of magnesium alloys extracts on adult human bone marrow-derived stromal cell viability and osteogenic differentiation[J]. Biomedical Materials (Bristol, England), 2010, 5(4):045005. [15] Wen Y F, Liu Q S, Wang J F, et al. Improving in vitro and in vivo corrosion resistance and biocompatibility of Mg-1Zn-1Sn alloys by microalloying with Sr[J]. Bioactive Materials, 2021, 6(12):4654-4669. [16] Zhuang J P, Jing Y B, Wang Y M, et al. Degraded and osteogenic properties of coated magnesium alloy AZ31: An experimental study[J]. Journal of Orthopaedic Surgery and Research, 2016, 11:30. [17] Wu H L, Zhang C J, Lou T F, et al. Crevice corrosion - A newly observed mechanism of degradation in biomedical magnesium[J]. Acta Biomaterialia, 2019, 98:152-159. [18] Wong H M, Yeung K W K, Lam K O, et al. A biodegradable polymer-based coating to control the performance of magnesium alloy orthopaedic implants[J]. Biomaterials, 2010, 31(8):2084-2096. [19] Zhao D L, Brown A, Wang T T, et al. In vivo quantification of hydrogen gas concentration in bone marrow surrounding magnesium fracture fixation hardware using an electrochemical hydrogen gas sensor[J]. Acta Biomaterialia, 2018, 73:559-566. [20] Wang Z, Wang X Y, Pei J, et al. Degradation and osteogenic induction of a SrHPO4-coated Mg-Nd-Zn-Zr alloy intramedullary nail in a rat femoral shaft fracture model[J]. Biomaterials, 2020, 247:119962. [21] Wang C H, Yi Z L, Sheng Y F, et al. Development of a novel biodegradable and anti-bacterial polyurethane coating for biomedical magnesium rods[J]. Materials Science and Engineering: C, 2019, 99:344-356. [22] Wang C X, Fang H, Qi X Y, et al. Silk fibroin film-coated MgZnCa alloy with enhanced in vitro and in vivo performance prepared using surface activation[J]. Acta Biomaterialia, 2019, 91:99-111. [23] Wang C X, Fang H, Hang C J, et al. Fabrication and characterization of silk fibroin coating on APTES pretreated Mg-Zn-Ca alloy[J]. Materials Science and Engineering: C, 2020, 110:110742. [24] Zhang L, Pei J, Wang H D, et al. Facile preparation of poly(lactic acid)/brushite bilayer coating on biodegradable magnesium alloys with multiple functionalities for orthopedic application[J]. ACS Applied Materials & Interfaces, 2017, 9(11):9437-9448. [25] Zhang N, Liu N, Sun C, et al. In vivo study of a novel micro-arc oxidation coated magnesium-zinc-calcium alloy scaffold/autologous bone particles repairing critical size bone defect in rabbit[J]. Chinese Journal of Reparative and Reconstructive Surgery, 2018, 32(3):298-305. [26] Zaatreh S, Haffner D, Strauss M, et al. Thin magnesium layer confirmed as an antibacterial and biocompatible implant coating in a co?culture model[J]. Molecular Medicine Reports, 2017, 15(4):1624-1630. [27] Zhang L, Jia G Z, Tang M, et al. Simultaneous enhancement of anti-corrosion, biocompatibility, and antimicrobial activities by hierarchically-structured brushite/Ag3PO4-coated Mg-based scaffolds[J]. Materials Science and Engineering: C, 2020, 111:110779. [28] Yan Y R, Wei Y, Yang R, et al. Enhanced osteogenic differentiation of bone mesenchymal stem cells on magnesium-incorporated titania nanotube arrays[J]. Colloids and Surfaces B: Biointerfaces, 2019, 179:309-316. [29] Zaatreh S, Haffner D, Strau? M, et al. Fast corroding, thin magnesium coating displays antibacterial effects and low cytotoxicity[J]. Biofouling, 2017, 33(4):294-305. [30] Yazdimamaghani M, Razavi M, Vashaee D, et al. Porous magnesium-based scaffolds for tissue engineering[J]. Materials Science and Engineering: C, 2017, 71:1253-1266. [31] Wang W H, Blawert C, Zan R, et al. A novel lean alloy of biodegradable Mg-2Zn with nanograins[J]. Bioactive Materials, 2021, 6(12):4333-4341. [32] Wu Y H, He G P, Zhang Y, et al. Unique antitumor property of the Mg-Ca-Sr alloys with addition of Zn[J]. Scientific Reports, 2016, 6:21736. [33] Globig P, Willumeit-R?mer R, Martini F, et al. Optimizing an osteosarcoma-fibroblast coculture model to study antitumoral activity of magnesium-based biomaterials[J]. International Journal of Molecular Sciences, 2020, 21(14):5099. [34] Onder S, Calikoglu-Koyuncu A C, Kazmanli K, et al. Behavior of mammalian cells on magnesium substituted bare and hydroxyapatite deposited (Ti,Mg)N coatings[J]. New Biotechnology, 2015, 32(6):747-755. [35] Nayak S, Bhushan B, Jayaganthan R, et al. Strengthening of Mg based alloy through grain refinement for orthopaedic application[J]. Journal of the Mechanical Behavior of Biomedical Materials, 2016, 59:57-70. [36] Li M, Yao M Y, Wang W D, et al. Nitrogen-containing bisphosphonate-loaded micro-arc oxidation coating for biodegradable magnesium alloy pellets inhibits osteosarcoma through targeting of the mevalonate pathway[J]. Acta Biomaterialia, 2021, 121:682-694. [37] Anisimova N, Kiselevskiy M, Martynenko N, et al. Cytotoxicity of biodegradable magnesium alloy WE43 to tumor cells in vitro: Bioresorbable implants with antitumor activity?[J]. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 2020, 108(1):167-173. [38] 向春玲, 黄华军, 张雁儒. 快速高仿真人骨有限元几何建模—–基于Mimics、Geomagic及Ansys软件的应用[J]. 宁波大学学报(理工版), 2019, 32(6):16-22. [39] 张雁儒. 精准微创个体化医疗、3D打印及计算机导航技术在骨科临床的研究进展[J]. 宁波大学学报(理工版), 2019, 32(6):1-5. [40] 黄华军, 曾参军, 张雁儒. 3D打印结合内固定模型库辅助复杂胫骨平台骨折精确化内固定手术[J]. 宁波大学学报(理工版), 2019, 32(6):23-29. [41] 余进伟, 张雁儒, 郭甲瑞, 等. 髓芯减压联合陶瓷骨植入治疗中早期股骨头坏死的临床研究[J]. 宁波大学学报(理工版), 2019, 32(6):6-10. |
| 备注/Memo: | 收稿日期: 2021－10－27. 宁波大学学报（理工版）网址: http://journallg.nbu.edu.cn/ 基金项目: 河南省科技攻关重点项目（201402003）. 第一作者: 张雁儒（1970－）, 男, 河南西华人, 教授, 主要研究方向: 创伤骨科. E-mail: zyr@hpu.edu.cn 宁波大学学报（理工版）网址：http://journallg.nbu.edu.cn/ |
